（http://www.cpu.edu.cn）。

China Pharmaceutical University is a prestigious institution with a long history, distinctive features, and excellent academic atmosphere. It is directly affiliated with the Ministry of Education as one of the national Double First-Class universities (first-class discipline). It is among the first batch of higher education institutions in China authorized to grant doctoral and master's degrees. The university offers solid pharmacy and traditional Chinese medicine-related programs, along with various innovation platforms. Additionally, it offers a well-rounded and diverse curriculum that covers both pharmacy and traditional Chinese medicine disciplines. Please visit the official website http://www.cpu.edu.cn for more details.

一、課題組介紹

合作導師何牟欣亞，中國藥科大學教授，博士生導師，入選國家高層次人才計劃。2014年于新加坡南洋理工大學獲得博士學位并從事博士后研究，2022年8月加入中國藥科大學中藥學院。以第一作者（或者共同第一作者）在JACS, PNAS, ACS  Catalysis，New Phytologist，Organic Letters等國際知名期刊發表多篇研究論文，申請國際和國內發明專利2項。擔任Frontiers in Nutrition, Molecules等學術期刊特邀編委。

課題組主要從事穩定多肽藥物設計與合成研究。天然穩定多肽是一類尚未充分挖掘的可成藥活性分子，具有高穩定性，高生物利用度，是生物藥的優秀先導體。然其機理研究和成藥性受到天然低表達量的局限，因此對其合成途徑的解析和人工合成的技術研發是以天然穩定多肽為基礎進行新藥研發的關鍵。

課題組的主要研究方向為：

1)天然多肽合成酶的系統性挖掘、設計改造及藥物合成應用

2)穩定活性多肽的化學合成技術研發

3)基于穩定多肽骨架的多肽藥物設計、虛擬篩選及活性驗證

因課題組發展需要，現公開招聘博士后2名，長期有效。課題組保障待遇并全力支持博士后的科研發展，誠邀海內外英才加入。

The group leader is Professor Xinya Hemu, recipient of China Pharmaceutical University’s High-Level Talent Introduction Program, NCSF Distinguished Overseas Young Talent. She received her Ph.D. from Nanyang Technological University, Singapore, in 2014 and pursued postdoctoral research before joining the School of Traditional Chinese Medicine at China Pharmaceutical University in August 2022. As the first author (or co-first author), she has published numerous research articles in internationally renowned journals such as JACS, PNAS, ACS Catalysis, New Phytologist, and Organic Letters, and has applied for two international and domestic patents. She is also an invited editor for academic journals such as Frontiers in Nutrition and Molecules.

Hemu’s research group primarily focuses on the design and synthesis of stable peptide drugs. Natural stable peptides are a class of underexplored drug-like active molecules with high stability and high bioavailability, making them excellent precursors for biopharmaceuticals. However, their mechanistic research and druggability are limited by their low natural expression levels. Therefore, the analysis of their synthetic pathways and the development of artificial synthesis techniques are critical for new drug development based on natural stable peptides.

The main research areas include:

(1)Systematic study of natural peptide synthetic enzymes on discovery, design, modification, and application on drug synthesis

(2)Development of chemical synthesis technology for stable active peptides

(3)Peptide drug design based on stable peptide scaffolds, virtual screening, and functional validation

Two post-doctoral positions are open for application with no immediate closing date. The research group guarantees compensation, and fully supports the scientific research development of postdoctoral researchers.

二、招聘崗位

崗位1：已經或即將獲得生物信息學、計算生物學、結構生物學等相關專業的博士學位并有長遠科研事業規劃的申請人，優先考慮具有酶學相關研究背景的候選人。

工作內容：

1.蛋白結構/動力學/量子力學計算、功能-結構關系圖譜的機器學習模型構建、藥物虛擬篩選平臺構建等相關科研工作；

2.協助進行項目申請和管理；

3.協助指導研究生的科研工作

崗位2：已經或即將獲得生物學或藥學等相關專業的博士學位并有長遠科研事業規劃的申請人，優先考慮具有細胞生物學、實驗動物學、電生理學背景的博士。

工作內容：

1.先導藥物的體內外活性檢測平臺搭建，藥理分析等相關科研工作；

2.協助進行項目申請和管理；

3.協助指導研究生的科研工作

應聘條件：

（1）以第一作者身份在SCI雜志上發表論文或者已經接收；

（2）具有專業的寫作和閱讀能力，能夠積極追蹤所研究方向的前沿論文，可獨立完成SCI論文的寫作；

（3）具備良好溝通和執行能力，可在指導下獨立開展課題研究和項目管理；

（4）熱愛科研、積極樂觀、有很強的責任心和團隊合作意識，有堅定的學術追求。 

Position #1: PhD students who are nearing the completion of or have recently completed their studies in Bioinformatics / Computational biology / Structural Biology and are considering a postdoctoral position as the next stage in their career development. Priority will be given to candidates with a research background in enzymology.

Responsibilities:

1.Research work related to protein structure, MD, QM/MM, machine learning model construction for structure-function relationship atlas, development of virtual screening platform;

2.Assist in grant application and management;

3.Guide graduate students in their research work.

Position #2: PhD students who are nearing the completion of or have recently completed their studies in Biology / Pharmacology and are considering a postdoctoral position as the next stage in their career development. Priority will be given to candidates with a research background in cell biology, experimental animal science, and electrophysiology.

Responsibilities:

1.Research works related to the establishment of in vitro and in vivo activity testing platforms for lead drugs, as well as pharmacological analysis;

2.Assist in grant application and management;

3.Guide graduate students in their research work.

Requirements:

1.Have published articles(or with the acceptance letter) as the first author in peer-reviewed SCI journals;

2.Professional writing and reading skills, able to actively track recent research papers in the field, and independently complete SCI article writing;

3.Strong communication and execution skills, capable of conducting research independently and managing project under guidance;

4.Passionate about scientific research, positive and optimistic, with a strong sense of responsibility and team collaboration, with a determined pursuit of academic excellence.

三、崗位待遇

1、根據個人情況，聘為興藥科研博士后（年薪約29萬）。同時博士后人員在站期間，享受公費醫療、公積金以及校工會有關待遇。在教學和科研方面取得突出成果，可享受學校相應的獎勵政策。出站后，可申報具有正式編制的講師或副研究員。具體要求及待遇詳情請參見《中國藥科大學博士后工作管理辦法（試行）》https://rsc.cpu.edu.cn/67/83/c4819a157571/page.htm。

2、課題組協助申報國家、省部級課題及相關機構提供的博士后資助（如江蘇省卓越博士后計劃（15萬/年）等）。 

Benefits

The shortlisted candidate will be appointed as a postdoctoral researcher in pharmaceutical sciences with an annual salary of approximately 280,000 RMB. During the postdoctoral period, the researcher will enjoy employee benefits (public medical insurance, housing provident fund, and benefits related to the university labor union). Those who achieve outstanding results in teaching and research can enjoy the corresponding reward policies of the university. After completing the postdoctoral position, candidates can apply for a formal lecturer or associate researcher position. For specific requirements and compensation details, please refer to “China Pharmaceutical University Postdoctoral Work Management Measures (Trial Implementation)” https://rsc.cpu.edu.cn/67/83/c4819a157571/page.htm.

The research group will assist in applying for national, provincial, and ministerial-level projects, as well as postdoctoral funding provided by relevant organizations (e.g. Outstanding Postdoctoral Program of Jiangsu province (150,000 RMB/year) ).

四、申請材料 Documents for application

·個人簡歷及相關支持材料Resume and supporting documents

·代表性科研成果Representative Research Achievements

·求職信（簡述科研興趣和發展規劃）Cover letter (Briefly introduce your research interests and future plan)

·3 封推薦信（由推薦人直接發送至聯系人郵箱）Three recommendation letters (to be sent directly by the recommender to the contact’s email)

五、應聘方式

請應聘者將申請材料通過電子郵件發送至hemuxinya@cpu.edu.cn（何老師）。郵件標題請注明：“應聘博士后+姓名+高校人才網”字樣。應聘材料將予以嚴格保密。經初步審核通過者，課題組將盡快安排面試。

How to apply

Interested applicants should send their application materials (except the recommendation letters) via email to hemuxinya@cpu.edu.cn (Dr. Hemu). Please indicate Postdoc Application + Your Name in the email subject line. All application materials will be treated with strict confidentiality. After an initial review, the research group will arrange interviews for qualified candidates as soon as possible.

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